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生物信息学院学术讲座—Proteomics in China and the challenge in proteomics bioinformatics
来自:学术活动 发布时间:2017年05月19日 09:05 发表人:

    

生物信息学院学术讲座—Proteomics in China and the challenge in proteomics bioinformatics

    讲座题目:Proteomics in China and the challenge in proteomics bioinformatics

     主讲嘉宾:秦钧,北京蛋白质组研究中心主任

    讲座时间:2017520日(星期900

    讲座地点:逸夫楼205会议室

    主办单位:重庆邮电大学生物信息学

 

    报告摘要:

    As the performance of mass spectrometer (MS) and large-scale protein sequencing has been improved over the last few years, pushing the proteome analysis to the level that is compatible to mRNA-seq. The development of affinity-based reagents that target sub-proteomes that may correlate with activities, such as transcription factor (TF) DNA binding activity and post-translational modification (PTM) (especially for phosphorylation, ubiquitilation, and acetylation) has further extended proteomics to low abundant but functionally important proteins. Coupling with a fast screening (Fast-seq) approach developed recently, proteomics nowadays can achieve dual high-throughput in both number of protein identification and number of sample measured. Now it seems that proteomics has established its technology platforms to rival genomics and transcriptomics.

    China is at the leading edge of catching the wave of rapid development in proteomics. A National Center for Protein Sciences (dubbed the Phoenix project) was announced in October 2015. This center is filled with cutting edge proteomics technologies and state-of-the-art proteomics instruments. It has the capacity of measuring 10 proteomes per day. Such an analysis power will be shared with scientists working on proteins, biology and medicine in China and the world.

In 2014, Ministry of Science and Technology approved the Chinese Human Proteome Project (CNHPP). This is a large undertaking at dissection of the proteomic landscape of cancer. Alteration of Signaling pathways in 10 cancers that have major impacts in health and economy in China will be mapped through the collective efforts of more than 40 labs in China.

    Proteomics has the ability to catch dynamic pathways that response to biological processes, especially for PTM-dependent signal transductions, transcription factor activity related transcriptional regulation, and protein-protein interactions (PPI). Proteomics sets itself apart from other omics that it offers multi-dimensional data and provides direct information on what is happening inside the cell. I will summarize recent development and current capability of proteomics for biological research and discuss future direction of proteomics for translational medicine.

 

      随着过去几年质谱仪(MS)和大规模蛋白质测序性能的提升,蛋白质组分析也达到能与mRNA测序相比较的水平。以亲和性试剂为基础的亚蛋白质组学可以关联许多反应,比如转录因子(TFDNA结合活性和翻译后修饰(PTM)(特别是磷酸化,泛素化和乙酰化),并能进一步将蛋白质组学扩展到具备重要功能的低丰度蛋白质。与近来开发的快速筛选(Fast-seq)方法结合,蛋白质组学可以实现在蛋白质鉴定和样品数量的双重高通量测定。现在,蛋白质组学似乎已经建立起与其基因组学和转录组学技术相抗衡的技术平台。

        中国已处于快速发展的蛋白质组学潮流的前沿。国家蛋白质科学中心 北京(被称为凤凰项目)于201510月被宣布。该中心拥有最尖端蛋白质组学技术和最先进的蛋白质组学仪器。它具有每天测量10个蛋白质组的能力。他们的平台将与中国和世界上从事蛋白质、生物学和医学研究的科学家共享测序和分析资源。

        2014年,中国科技部批准了中国人类蛋白质组计划(CNHPP)。这是深入研究癌症蛋白质组学的重大事业。通过中国40多家研究机构的共同努力,CNHPP绘制出10个对中国健康和经济产生重大影响的癌症信号通路改变图谱。

蛋白质组学有能力捕捉响应生物过程的动态通路,特别是对于依赖于翻译后修饰的信号转导、转录因子活性相关的转录调节以及蛋白质-蛋白质相互作用(PPI)。蛋白质组学提供多维数据,并提供有关细胞内动态的直接信息。我将总结蛋白质组学最近的发展和现有的生物学研究能力,并讨论了蛋白质组学在转化医学领域的的未来发展方向。

 

嘉宾简介:

    秦钧,博士,现任北京蛋白质组研究中心主任、研究员,博士生导师,中组部“千人计划”人才。中国生物化学与分子生物学会蛋白质组学专业委员会(CNHUPO) 理事长。秦钧教授是世界上少数几位将质谱仪设计、蛋白质组学方法开发、生物信息学、生物学及临床应用纳入同一个研究项目的学者之一。在CellNat BiotechnolMol CellAnal Chem,  PNASNat CommuJ Proteome ResJBC等国内外杂志发表论文百余篇。

欢迎感兴趣的老师和同学们参加!

 

                                                                                                                                      生物信息学院

                                                                                                                                     2017519

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